The anode catalysts of SPE water electrolysis are currently involving precious metal Ir, Ru-based catalysts, multi-element metal oxides, single-atom catalysts and non-precious metals. Ir, Ru-based catalysts have the highest activity and stability under acidic conditions. Adjusting the composition, morphology, structure, and carrier of the Ir, Ru-based catalysts is the main direction for the acidic OER catalysts development. Cathode catalysts mainly include Pt-based catalysts, non-Pt noble metal-based catalysts, single-atom catalysts and non-precious metal materials. Although the activity of precious metal catalysts such as Pt is high, the cost is very high as well. The development of non-precious metal materials with high activity and stability has become a hotspot in this research filed. We have developed in-situ semi-mosaic and surface rich clustering methods, in which Pt clusters are enriched and anchored to the surface of the PtRu catalyst, and the resulting catalyst loading is only 0.2%. Nevertheless, the performance is equivalent to that of a commercial 20% catalyst. We have also created a thermodynamically spontaneous single-atom interface doping method, through which we obtained a single-atom Pd-doped MoS2 hydrogen evolution catalyst. At the same time, the highly stable coordination mode of Pd enables the catalyst to be activated while its stability is also improved. The high-performance nano-catalyst material we developed was successfully applied to the electrolysis device of a hydrogen energy company, which greatly reduced its cost and increased market competitiveness. In another project, we integrated electrolysis units with a total power of 30kW. The electrolytic stack can work at a temperature range of -10°C to 80°C. After working for more than 3200 hours (about two years), the performance is still stable and there is no obvious attenuation.